Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.9K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.2K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

952
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
952
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

547
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
547

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High Azole Resistance in Aspergillus fumigatus Isolates from Strawberry Fields, China, 2018.

Emerging infectious diseases·2019
Same author

Association between family management and asthma control in children with asthma.

Journal for specialists in pediatric nursing : JSPN·2019
Same author

BACH2 regulates the function of human CD4<sup>+</sup> CD45RA<sup>-</sup> Foxp3<sup>l</sup> ° cytokine-secreting T cells and promotes B-cell response in systemic lupus erythematosus.

European journal of immunology·2019
Same author

Serotypes and virulence genes of Pseudomonas aeruginosa isolated from mink and its pathogenicity in mink.

Microbial pathogenesis·2019
Same author

Comparison of Two Typing Methods for Characterization of Azole Resistance in Aspergillus fumigatus from Potting Soil Samples in a Chinese Hospital.

Antimicrobial agents and chemotherapy·2019
Same author

Total synthesis and anti-inflammatory evaluation of violacin A and its analogues.

Bioorganic chemistry·2019

Related Experiment Video

Updated: Feb 4, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K

[Autophagy and neuronal diseases].

Xiaolei Yang1, Xi Ran, Xuelian Liao

  • 1Department of Critical Care Medicine, Chongqing General Hospital, Chongqing 400013, China (Yang XL, Ran X); Department of Critical Care Medicine, West China Hospital, Chengdu 610041, Sichuan, China (Liao XL, Han L, Kang Y). Corresponding author: Kang Yan,

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|October 13, 2018
PubMed
Summary

Autophagy, a cellular recycling process, is crucial for maintaining homeostasis and plays a key role in nervous system diseases. Understanding its dynamic regulation is vital for treating neurodegenerative conditions.

More Related Videos

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
09:51

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells

Published on: June 30, 2023

1.5K

Related Experiment Videos

Last Updated: Feb 4, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
09:51

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells

Published on: June 30, 2023

1.5K

Area of Science:

  • Cellular Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Autophagy is a fundamental cellular process for recycling proteins and organelles, essential for maintaining cellular homeostasis.
  • Emerging evidence highlights the significant role of autophagy in the development of various neuronal diseases.
  • Dysfunctional autophagy contributes to the pathogenesis of common nervous system disorders.

Purpose of the Study:

  • To review the current research on the role of autophagy in the pathogenesis of common nervous system diseases.
  • To explore the regulatory mechanisms governing autophagy in neurological conditions.
  • To emphasize the importance of dynamic autophagy regulation and mitigating autophagic flow injury.

Main Methods:

  • Literature review of recent studies on autophagy and nervous system diseases.
  • Analysis of research on the molecular mechanisms of autophagy regulation.
  • Synthesis of findings related to autophagic dysfunction in neurodegeneration.

Main Results:

  • Autophagy is implicated in the pathogenesis of numerous nervous system diseases.
  • Specific regulatory pathways of autophagy are being identified in neurological disorders.
  • Disruptions in autophagic flux are a common feature in neurodegenerative conditions.

Conclusions:

  • Autophagy plays a critical role in the pathogenesis of nervous system diseases.
  • Further research into the dynamic regulation of autophagy is needed for therapeutic strategies.
  • Alleviating autophagic flow injury presents a promising avenue for treating neurodegenerative disorders.