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Pathophysiological Mechanisms in Cardiorenal Syndrome
Janani Rangaswami1, Roy O Mathew1
1Department of Medicine, Division of Nephrology, Einstein Medical Center; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA; and Division of Nephrology, William Jennings Bryan Dorn VA Medical Center, Columbia, SC.
Advances in Chronic Kidney Disease
|October 13, 2018
Summary
Cardiorenal syndrome involves complex heart-kidney interactions. Recent advances in defining phenotypes and using biomarkers promise improved diagnosis and precision medicine for better patient outcomes.
Area of Science:
- Cardiology
- Nephrology
- Pathophysiology
Background:
- Cardiorenal syndrome (CRS) involves complex interactions between the heart and kidneys.
- Pathophysiological mechanisms include hemodynamic, neurohormonal, and inflammatory pathways.
- Historical understanding of CRS has evolved significantly.
Purpose of the Study:
- To review recent advancements in CRS definition, phenotyping, and classification.
- To highlight the role of advanced diagnostic strategies, particularly biomarkers.
- To discuss the integration of precision medicine in CRS management.
Main Methods:
- Review of historical experiments and recent decade advancements.
- Analysis of diagnostic strategies and cardiorenal biomarkers.
- Discussion on integrating pathophysiology for precision medicine.
Main Results:
- Streamlined definitions, phenotypes, and classifications for CRS.
- Emerging role of cardiorenal biomarkers for accurate delineation.
- Potential for precision medicine in diagnosis and treatment.
Conclusions:
- Characterizing CRS by pathophysiology is crucial.
- Advanced biomarkers aid in phenotype delineation and prognosis.
- Precision medicine integration promises reduced morbidity and mortality.
Keywords:
CardiorenalCentral venous pressuresDiuretic resistanceIntraabdominal pressureRenin-angiotensin-aldosterone systemMore Related Videos
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