Pathophysiological Mechanisms in Cardiorenal Syndrome

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Janani Rangaswami1, Roy O Mathew1

  • 1Department of Medicine, Division of Nephrology, Einstein Medical Center; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA; and Division of Nephrology, William Jennings Bryan Dorn VA Medical Center, Columbia, SC.

Advances in Chronic Kidney Disease
|October 13, 2018
PubMed

Insights

Cardiorenal syndrome involves complex heart-kidney interactions. Recent advances in defining phenotypes and using biomarkers promise improved diagnosis and precision medicine for better patient outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Pathophysiology

Background:

  • Cardiorenal syndrome (CRS) involves complex interactions between the heart and kidneys.
  • Pathophysiological mechanisms include hemodynamic, neurohormonal, and inflammatory pathways.
  • Historical understanding of CRS has evolved significantly.

Purpose of the Study:

  • To review recent advancements in CRS definition, phenotyping, and classification.
  • To highlight the role of advanced diagnostic strategies, particularly biomarkers.
  • To discuss the integration of precision medicine in CRS management.

Main Methods:

  • Review of historical experiments and recent decade advancements.
  • Analysis of diagnostic strategies and cardiorenal biomarkers.
  • Discussion on integrating pathophysiology for precision medicine.

Main Results:

  • Streamlined definitions, phenotypes, and classifications for CRS.
  • Emerging role of cardiorenal biomarkers for accurate delineation.
  • Potential for precision medicine in diagnosis and treatment.

Conclusions:

  • Characterizing CRS by pathophysiology is crucial.
  • Advanced biomarkers aid in phenotype delineation and prognosis.
  • Precision medicine integration promises reduced morbidity and mortality.

Keywords:
CardiorenalCentral venous pressuresDiuretic resistanceIntraabdominal pressureRenin-angiotensin-aldosterone system

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