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Toward Precision Medicine in the Cardiorenal Syndrome

Nicholas Wettersten1, Alan S Maisel1, Dinna N Cruz1

  • 1Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA; and Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California.

Advances in Chronic Kidney Disease
|October 13, 2018
PubMed

Insights

Precision medicine is lacking in cardiorenal syndrome care. Biomarkers are needed to personalize treatment for worsening renal function (WRF) in acute heart failure, improving patient outcomes.

Area of Science:

  • Cardiology and Nephrology
  • Cardiorenal Syndrome
  • Precision Medicine

Background:

  • Cardiology and nephrology lag behind oncology in adopting precision medicine.
  • A "one size fits all" approach is common in managing cardiorenal syndrome.
  • The prognostic impact of worsening renal function (WRF) in acute heart failure is highly variable.

Purpose of the Study:

  • To review current cardiac and renal biomarkers for cardiorenal syndrome evaluation.
  • To highlight the need for biomarkers to guide precise care for WRF in acute heart failure.
  • To assess the current status of biomarkers in clinical practice for cardiorenal syndrome.

Main Methods:

  • Literature review of current cardiac and renal biomarkers.
  • Analysis of biomarker utility in assessing cardiorenal syndrome.
  • Evaluation of the potential for biomarkers in precision medicine for cardiorenal syndrome.

Main Results:

  • Current biomarkers offer insights but are insufficient for routine precision care in cardiorenal syndrome.
  • Significant variability exists in the prognostic implications of WRF.
  • Real-time physiological evaluation via biomarkers is crucial for personalized WRF management.

Conclusions:

  • Further research is essential to integrate precision medicine into cardiorenal syndrome management.
  • Biomarker development is key to differentiating WRF implications and tailoring treatments.
  • Bridging the gap between research and clinical practice is needed for advanced cardiorenal care.
Keywords:
Acute kidney injuryCardiorenal syndromePrecision medicine

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