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Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy

Liwen Liu1, Jing Li1, Lei Zuo1

  • 1Xijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Journal of the American College of Cardiology
|October 13, 2018
PubMed

Insights

Percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) offers a safe and effective treatment for hypertrophic obstructive cardiomyopathy (HOCM). This procedure significantly reduces left ventricular outflow tract gradients and improves patient exercise capacity and cardiac function.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Ablation Techniques

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) can cause disabling symptoms.
  • Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) presents a potentially less invasive therapeutic option.

Purpose of the Study:

  • To evaluate the safety and efficacy of PIMSRA.
  • To assess the reduction of left ventricular outflow tract (LVOT) gradients in HOCM patients.

Main Methods:

  • Fifteen patients diagnosed with HOCM were enrolled.
  • Procedures included electrocardiography, imaging, and blood biochemistry.
  • A 6-month follow-up period was implemented.

Main Results:

  • Significant reductions in both resting and stress-induced LVOT gradients were observed (p < 0.005).
  • Interventricular septum (IVS) thickness decreased significantly (p < 0.001).
  • Improvements noted in New York Heart Association functional class, exercise time, and pro-BNP levels (p < 0.028).

Conclusions:

  • PIMSRA is a safe and effective treatment for severe, symptomatic HOCM.
  • The procedure leads to sustained improvements in exercise capacity and cardiac function.
  • Persistent reduction in LVOT gradient was achieved.
Abstract

Keywords:
echocardiography-guided septal ablationhypertrophic obstructive cardiomyopathypercutaneous intramyocardialradiofrequency septal ablation

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