Related Experiment Video

Updated: Feb 4, 2026

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
08:42

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

4.2K

Initial Experience of the Use of 3-Factor Prothrombin Complex Concentrate and Thromboembolic Complications After

India Zweng1, Sean Galvin2, Ray Robbins3

  • 1Department of Surgery, Austin Hospital, Melbourne, Vic, Australia.

Heart, Lung & Circulation
|October 13, 2018
PubMed

Insights

Three-factor prothrombin complex concentrate (3F-PCC) use in cardiac surgery patients did not show an increased risk of thromboembolic events compared to conventional therapy. This study suggests 3F-PCC is a safe option for managing coagulopathy.

Area of Science:

  • Cardiology
  • Hematology
  • Anesthesiology

Background:

  • 3-factor prothrombin complex concentrate (3F-PCC) is a potential treatment for coagulopathy in cardiac surgery.
  • Concerns exist regarding 3F-PCC's potential to increase thromboembolic events.

Purpose of the Study:

  • To compare the incidence of thromboembolic events in cardiac surgery patients treated with 3F-PCC versus conventional therapy.

Main Methods:

  • Retrospective cohort study comparing patients who received 3F-PCC with a control group.
  • Propensity-score matching was used for risk adjustment.
  • Demographic, operative, and postoperative data were analyzed.

Main Results:

  • Patients receiving 3F-PCC were younger and had fewer comorbidities but underwent more complex surgeries.
  • Unadjusted and adjusted 30-day mortality and readmission rates were similar between groups.
  • The incidence of thromboembolic events was comparable between the 3F-PCC and control groups (9.2% vs. 6.8%, p=0.40), with adjusted odds ratio of 1.512 (p=0.541).

Conclusions:

  • 3-factor prothrombin complex concentrate was administered to patients at higher risk for bleeding complications.
  • Initial findings suggest that 3F-PCC use does not elevate thromboembolic risks compared to conventional treatments in cardiac surgery.
Abstract

Keywords:
Cardiac surgeryCoagulopathyProthrombin complex concentrateThromboembolic complications

More Related Videos

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs10:37

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs

Published on: May 10, 2018

13.1K
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

10.0K

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Initiation of Translation02:33

Initiation of Translation

8.1K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
849
Solution Concentration and Dilution02:59

Solution Concentration and Dilution

The relative amount of a given solution component is known as its concentration. Often, though not always, a solution contains one component with a concentration that is significantly greater than that of all other components. This component is called the solvent and may be viewed as the medium in which the other components are dispersed or dissolved. Solutions in which water is the solvent are, of course, very common on our planet. A solution in which water is the solvent is called an aqueous...
133.8K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.9K