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Related Concept Videos

Thoracic Aorta01:15

Thoracic Aorta

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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The Thoracic Cage: Sternum01:17

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The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
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The Thoracic Cage: Ribs01:20

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Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
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Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

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A New Murine Model of Endovascular Aortic Aneurysm Repair
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[Endovascular Technology for Thoracic Aortic Pathology].

Masaaki Kato1

  • 1Department of Cardiovascular Surgery, Morinomiya Hospital, Osaka, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|October 13, 2018
PubMed
Summary

Stent-graft technology has advanced significantly over 25 years, expanding applications in complex aortic conditions. Continued innovation promises less invasive treatments and improved outcomes for thoracic aortic diseases.

Area of Science:

  • Vascular Surgery
  • Medical Device Technology
  • Cardiovascular Interventions

Background:

  • Stent-graft technology has been utilized for 25 years.
  • Initial applications have expanded to complex aortic regions.

Purpose of the Study:

  • To review the evolution and expanded applications of stent-graft technology.
  • To highlight advancements in treating thoracic aortic pathologies.

Main Methods:

  • Review of stent-graft development and application.
  • Focus on specific devices like frozen elephant trunk and fenestrated/branched grafts.
  • Analysis of expanded use in aortic arch and thoracoabdominal areas.

Main Results:

  • Significant progress in stent-graft technology over two decades.

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  • Wider applicability including aortic arch and thoracoabdominal interventions.
  • Development of specialized grafts like frozen elephant trunk and fenestrated/branched stent grafts.

    • Conclusions:

    • Stent-graft technology has matured, enabling broader clinical use.
    • Ongoing advancements are crucial for improving patient care.
    • Future developments will likely lead to more minimally invasive options for thoracic aortic conditions.