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Updated: Feb 4, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
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[Implantable Ventricular Assist Device].

Kan Nawata1, Minoru Ono

  • 1Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|October 13, 2018
PubMed
Summary
This summary is machine-generated.

Implantable ventricular assist devices (VADs) offer long-term circulatory support for advanced heart failure patients. These devices can improve quality of life and potentially reduce medical costs, representing a promising treatment option.

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Stage D refractory heart failure requires advanced therapeutic strategies.
  • Current guidelines include ventricular assist devices (VADs), heart transplantation, and terminal care.
  • Implantable VADs provide long-term circulatory support, with several devices available in Japan since 2011.

Purpose of the Study:

  • To evaluate the role and potential of implantable VADs in managing advanced heart failure.
  • To explore the application of VADs as destination therapy for non-transplant candidates.
  • To assess the impact of VADs on patient symptoms, quality of life, and healthcare expenses.

Main Methods:

  • Review of current therapeutic guidelines for stage D refractory heart failure.
  • Description of implantable VAD technology and its components.
  • Discussion of VADs as destination therapy and their availability in Japan.

Main Results:

  • Implantable VADs are a viable long-term support option for severe heart failure.
  • Destination therapy with VADs enables patients ineligible for transplantation to improve their quality of life.
  • Successful VAD implementation could lead to symptom improvement and reduced medical costs.

Conclusions:

  • Implantable VADs represent a significant advancement in treating refractory heart failure.
  • Destination therapy broadens the applicability of VADs, offering hope for improved patient outcomes.
  • Further evidence on symptom improvement and cost-effectiveness could drive wider adoption of VAD therapy.