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Updated: Feb 4, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
[Implantable Ventricular Assist Device]
1Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan.
Insights
Implantable ventricular assist devices (VADs) offer long-term circulatory support for advanced heart failure patients. These devices can improve quality of life and potentially reduce medical costs, representing a promising treatment option.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Stage D refractory heart failure requires advanced therapeutic strategies.
- Current guidelines include ventricular assist devices (VADs), heart transplantation, and terminal care.
- Implantable VADs provide long-term circulatory support, with several devices available in Japan since 2011.
Purpose of the Study:
- To evaluate the role and potential of implantable VADs in managing advanced heart failure.
- To explore the application of VADs as destination therapy for non-transplant candidates.
- To assess the impact of VADs on patient symptoms, quality of life, and healthcare expenses.
Main Methods:
- Review of current therapeutic guidelines for stage D refractory heart failure.
- Description of implantable VAD technology and its components.
- Discussion of VADs as destination therapy and their availability in Japan.
Main Results:
- Implantable VADs are a viable long-term support option for severe heart failure.
- Destination therapy with VADs enables patients ineligible for transplantation to improve their quality of life.
- Successful VAD implementation could lead to symptom improvement and reduced medical costs.
Conclusions:
- Implantable VADs represent a significant advancement in treating refractory heart failure.
- Destination therapy broadens the applicability of VADs, offering hope for improved patient outcomes.
- Further evidence on symptom improvement and cost-effectiveness could drive wider adoption of VAD therapy.
Abstract:
For patients with "stage D refractory heart failure" as stated by the The Japanese Circulation Society (JCS) 2017/The Japanese Heart Failure Society (JHFS) 2017 Guidelines for Diagnosis and Treatment of Acute and Chronic Heart Failure, extensive therapeutic methods including implantation of ventricular assist device (VAD) and/or heart transplantation, as well as terminal care. An implantable VAD is a device designed to support patients for a long term of several years. This device has its most part buried in the body with its driveline penetrated out through the skin to connect with a controller and butteries. In Japan, implantable VADs started to be used in 2011, and now 3 devices are available in a commercial basis, that is, EVAHEART 2, HeartMate II and Jarvik 2000. They are available when a patient has been listed as a candidate for heart transplantation, and recently the usage of implantable VAD as destination therapy that is applied for patients who are not eligible for heart transplantation but would get benefit from circulatory support, enough to be free from hospital-bound status and enjoy high quality of life. If this device can prove to improve heart failure patients' symptoms, resulting in decreasing medical expense, surely it would be widely accepted as a promising therapy to treat heart failure.
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