Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
Shwu-Jiuan Sheu1,2, Ying-Yen Lee1, Yu-Harn Horng1
1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com.
Purpose:
To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment.
Patients And Methods:
OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed.
Results:
Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 μm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage.
Conclusion:
DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME.
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