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Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched
Sung-Eun Kim1, Eun Sun Jang2, Moran Ki3
1Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Journal of Korean Medical Science
|October 13, 2018
Summary
Chronic Hepatitis B virus (HBV) infection is linked to chronic kidney disease (CKD). HBV surface antigen positivity was independently associated with reduced glomerular filtration rate and proteinuria, particularly in men.
Area of Science:
- Nephrology
- Hepatology
- Infectious Diseases
Background:
- Hepatitis B virus (HBV) infection can cause kidney problems.
- The link between HBV and chronic kidney disease (CKD) requires further investigation.
Purpose of the Study:
- To investigate the association between chronic HBV infection and CKD.
- To assess the prevalence of reduced glomerular filtration rate (GFR) and proteinuria in HBV-infected individuals.
Main Methods:
- A nationwide multicenter study included 265,086 participants.
- Hepatitis B surface antigen (HBsAg) positive cases (n=10,048) were compared to HBsAg negative controls (n=40,192).
- CKD was defined by GFR < 60 mL/min/1.73 m² or proteinuria (≥ 2+).
Main Results:
- HBsAg positive individuals had a higher prevalence of reduced GFR (3.3% vs 2.6%) and proteinuria (18.9% vs 14.1%) compared to controls (P < 0.001).
- HBsAg positivity was an independent risk factor for reduced GFR and proteinuria.
- HBsAg positive men showed a significantly increased risk for reduced GFR.
Conclusions:
- Chronic HBV infection is significantly associated with reduced GFR and proteinuria.
- Clinical monitoring for CKD is recommended for patients with chronic HBV infection, especially males.
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