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Published on: April 24, 2014
Exploration of biocompatible AIEgens from natural resources
Yuan Gu1,2, Zheng Zhao1,2, Huifang Su1,2
1Department of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China .
Abstract:
Luminogens with aggregation-induced emission (AIEgens) characteristics have been well developed and applied in various areas such as bio-imaging, theranostics, organic photoelectronics and chemo/bio sensors. However, most of the reported AIEgens suffer from the disadvantages of complex organic synthesis and high cost, as well as being environmentally unfriendly and hard to degrade, which have largely limited their real applications. In this work, we discovered berberine chloride, a natural isoquinoline alkaloid isolated from Chinese herbal plants, as an unconventional rotor-free AIEgen with bright solid-state emission and water-soluble characteristics. Single crystal structure analysis and optical property, viscosity, and host-guest interaction studies suggested that intramolecular vibration and twisted intramolecular charge transfer were responsible for the AIE phenomenon of berberine chloride. Moreover, berberine chloride was biocompatible and could specifically target lipid droplets in a fluorescence turn-on and wash-free manner, demonstrating the great potential of natural products as promising AIE probes.
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