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Updated: Feb 4, 2026

Isolation of Human Umbilical Vein Endothelial Cells HUVEC
Published on: April 28, 2007
Persistent right umbilical vein: a study using serial sections of human embryos and fetuses
Ji Hyun Kim1, Zhe Wu Jin2, Gen Murakami3
1Department of Anatomy and Institute of Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea.
Persistent right umbilical vein (PRUV) is a common venous anomaly. This study suggests a new type of PRUV where the right umbilical vein drains into the left liver, not just the right.
Area of Science:
- Embryology
- Vascular Anatomy
- Congenital Anomalies
Background:
- Persistent right umbilical vein (PRUV) is a recognized anomaly in human venous development.
- Previous assumptions suggested PRUV prevalence increases with earlier embryonic development.
Observation:
- Examination of 58 human embryos/fetuses (5-7 weeks gestation) revealed only two potential PRUV candidates.
- One specimen showed a degenerating right umbilical vein (UV) merging with a dominant left UV.
- Another specimen displayed a degenerating left UV joining a prominent right UV near the liver.
Findings:
- In both observed cases, the umbilical vein system ultimately drained into the left liver.
- This suggests a potential variant of PRUV where the right UV connects to the left liver, distinct from the typical right-sided drainage.
Implications:
- These findings challenge existing understanding of PRUV development and drainage patterns.
- Identifies a previously unrecognized anatomical variation in the fetal venous system.
- May necessitate revised diagnostic criteria and imaging protocols for fetal venous anomalies.
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10:25High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells
Published on: August 13, 2016
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