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miR-455-5p downregulation promotes inflammation pathways in the relapse phase of relapsing-remitting multiple

Shukoofeh Torabi1, Mona Tamaddon1, Mojtaba Asadolahi1

  • 1Stem Cell Technology Research Center, Tehran, Iran.

Immunogenetics
|October 13, 2018
PubMed

Insights

MicroRNA-455-5p (miR-455-5p) shows anti-inflammatory effects in multiple sclerosis (MS) by targeting MyD88 and REL. This discovery offers potential new strategies for managing MS severity and inflammation.

Area of Science:

  • Immunology
  • Neuroscience
  • Molecular Biology

Background:

  • Multiple sclerosis (MS) is a neurodegenerative disease driven by autoimmune inflammation.
  • Interleukin-10 (IL-10) induces microRNA-455-5p (miR-455-5p), suggesting an anti-inflammatory role.
  • The function and expression of miR-455-5p in MS pathogenesis remain largely unknown.

Purpose of the Study:

  • To investigate the expression level and role of miR-455-5p in multiple sclerosis (MS).
  • To determine if miR-455-5p targets inflammatory mediators MyD88 and REL in MS.

Main Methods:

  • Correlation analysis of miR-455-5p expression with disease severity in MS patients.
  • Luciferase assays to validate direct targeting of MyD88 and REL by miR-455-5p.
  • Analysis of miR-455-5p expression in relation to its predicted inflammatory targets in different MS phases.

Main Results:

  • miR-455-5p expression levels were significantly correlated with MS disease severity.
  • Inverse correlation observed between miR-455-5p and its targets MyD88 and REL in relapsing-remitting MS patients.
  • Luciferase assays confirmed MyD88 and REL as direct targets of miR-455-5p.

Conclusions:

  • This study is the first to report an anti-inflammatory role for miR-455-5p in multiple sclerosis (MS).
  • miR-455-5p exerts its anti-inflammatory effects, at least partially, by targeting MyD88 and REL.
  • miR-455-5p represents a potential novel therapeutic target for reducing inflammation and disease severity in MS.
Keywords:
InflammationMultiple sclerosisMyD88RELmiR-455-5p

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