Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K
The Placebo Effect01:54

The Placebo Effect

6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Threats to Biodiversity01:50

Threats to Biodiversity

27.1K
There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
27.1K
Genomics02:02

Genomics

40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of Paramedian Forehead Flap in an Octogenarian:A Case Report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2023
Same author

A Tailored mHealth App for Improving Health and Well-Being Behavioral Transformation in UK Police Workers: Usability Testing via a Mixed Methods Study.

JMIR human factors·2023
Same author

Drought priming induces chilling tolerance and improves reproductive functioning in chickpea (Cicer arietinum L.).

Plant cell reports·2022
Same author

Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling.

Molecular biology reports·2019
Same author

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis.

Investigational new drugs·2017

Related Experiment Video

Updated: Feb 4, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.1K

Vitex negundo and its medicinal value.

Balraj Singh Gill1,2, Richa Mehra1, Navgeet3

  • 1Department of Biosciences, Central University of Punjab, Bathinda, India.

Molecular Biology Reports
|October 13, 2018
PubMed
Summary

Vitex negundo (VN), a medicinal plant, contains bioactive compounds with anti-inflammatory and antioxidant properties. This review details VN

Keywords:
ApoptosisCancerReactive oxygen speciesSignalingVitex negundo

More Related Videos

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.8K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 4, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.1K
Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.8K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.4K

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Ethnobotany

Background:

  • Natural products offer potent bioactive compounds for disease treatment.
  • Vitex negundo (VN), or chaste tree, is ethnobotanically significant with diverse medicinal uses.
  • VN's chemical composition varies by species, yielding various phytochemicals.

Purpose of the Study:

  • To review updated information on Vitex negundo.
  • To explore its bioactive constituents and their mechanisms of action.
  • To highlight VN's therapeutic potential in various diseases.

Main Methods:

  • Literature review of ethnobotanical and pharmacological studies on Vitex negundo.
  • Analysis of phytochemical constituents and their biological activities.
  • Investigation of VN's impact on cellular signaling pathways.

Main Results:

  • VN yields bioactive compounds like flavonoids, lignans, and terpenes from its leaves, seeds, and roots.
  • These compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, and antimicrobial activities.
  • VN modulates key cellular events including apoptosis, cell cycle, and signaling pathways (MAPK, NF-κB, Akt).

Conclusions:

  • Vitex negundo possesses a rich array of bioactive compounds with significant therapeutic potential.
  • VN's constituents target multiple disease-related pathways, underscoring its medicinal value.
  • Further research and commercialization of VN-derived compounds are warranted.