Amyloid in the Brain, Alzheimer's on the Mind
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Updated: Sep 11, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Abstract:
Twenty percent of patients diagnosed with Alzheimer's disease by experts like me in fact don't have elevated amyloid and so, in fact, don't have Alzheimer's. What they do have is the subject of intense research, and there are many possibilities. A recent study of one thousand brain autopsies from older adults with a range of cognitive impairment showed at least 230 combinations of neuropathology. The point is that while the disease will be treatable, we're unlikely to defeat it as we did polio and smallpox. We're going to have to learn how to live with Alzheimer's as an at least somewhat treatable disease. To do so, we need to think outside the biomedical box.
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