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The Future of Migraine Prevention
1Department of Neurology, Stanford University, Oxnard, CA, USA.
Headache
|October 13, 2018
Summary
The first calcitonin gene-related peptide-based medications for migraine prevention are expected in 2018. This paper examines factors influencing their launch, access, and patient adherence in headache medicine.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine prevention has seen advances, yet novel therapeutic classes are emerging.
- Calcitonin gene-related peptide (CGRP)-based pharmaceuticals represent a new frontier.
Purpose of the Study:
- To analyze factors impacting the launch, access, compliance, and adherence of CGRP-based migraine preventatives.
- To contextualize these novel medications within the evolving landscape of headache medicine.
Main Methods:
- Review of class-specific and systems-based factors.
- Analysis of current and anticipated changes in headache medicine.
Main Results:
- Anticipated 2018 arrival of the first mechanism-specific migraine prevention class.
- Significant interest from the lay press and headache community in CGRP-based agents.
Conclusions:
- Successful integration of CGRP inhibitors depends on addressing launch, access, and adherence challenges.
- These novel agents are poised to reshape current and future headache medicine paradigms.
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