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Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
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Post-streptococcal glomerulonephritis: Some reduction in a disease of disparities

Alison M Vogel1,2, Diana R Lennon1,2,3, Bert van der Werf4

  • 1Department of Paediatrics, University of Auckland, New Zealand.

Journal of Paediatrics and Child Health
|October 13, 2018
PubMed

Insights

Acute post-streptococcal glomerulonephritis (APSGN) hospital admissions in children aged 0-14 years showed significant ethnic disparities, with Pacific and Māori children disproportionately affected. Rates declined overall from 2007-2015.

Area of Science:

  • Pediatric Nephrology
  • Epidemiology
  • Public Health

Background:

  • Acute post-streptococcal glomerulonephritis (APSGN) is a post-infectious kidney disease.
  • Understanding trends and disparities in APSGN hospital admissions is crucial for targeted public health interventions.

Purpose of the Study:

  • To assess trends and identify risk factors for hospital admissions due to APSGN in children aged 0-14 years in Auckland.
  • To highlight ethnic and socioeconomic disparities in APSGN incidence.

Main Methods:

  • Retrospective study of Auckland hospital admissions from 2007-2015.
  • Identification of APSGN cases using ICD-10 codes, validated against electronic clinical records and laboratory data.
  • Multivariate analysis to determine factors associated with admission risk.

Main Results:

  • A total of 430 APSGN cases were identified, with a mean annual incidence of 15.2/100,000 children.
  • Incidence was significantly higher in Pacific (50.2/100,000) and Māori (19.6/100,000) children compared to European/other populations (2.9/100,000).
  • Admission rates declined by 9.0% annually, but significant ethnic and deprivation-related disparities persisted. Key clinical findings included low C3 complement (94%) and hypertension (65%).

Conclusions:

  • Severe disparities exist in APSGN admission rates, with Pacific and Māori children facing a disproportionate disease burden.
  • Children from deprived circumstances are also at higher risk.
  • While overall rates trended downwards, the persistent disparities underscore the need for continued monitoring and intervention strategies.
Abstract

Keywords:
New Zealandepidemiologypost-streptococcal glomerulonephritis

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