Noradrenergic mechanisms in the response to dextroamphetamine in humans

The effect of oral thymoxamine, an alpha-noradrenergic antagonist, on the arousal and anorectic action of oral dextroamphetamine was measured in order to investigate the role of the alpha-noradrenergic pathways in these responses. Thymoxamine appeared to accentuate the alerting action and reduce the anorectic action of dextroamphetamine. The implications of these findings on the role of the alpha-noradrenergic pathways in these responses is discussed in the light of previous findings.