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Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Recent advances in microfluidic cell sorting techniques based on both physical and biochemical principles.

Wenlai Tang^1,2, Di Jiang³, Zongan Li¹

¹School of Electrical and Automation Engineering, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, P. R. China.

Electrophoresis

|October 13, 2018

Summary

Microfluidic cell sorting uses physical and biochemical methods for accurate cell isolation. Integrating these principles enhances techniques like magnetic-activated and fluorescence-activated cell sorting for improved performance.

Keywords:

Biochemical principle Cell sorting Microfluidics Physical principle

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Area of Science:

Biotechnology
Microfluidics
Cell Biology

Background:

Microfluidic cell sorting offers advantages like reduced sample use and high accuracy.
Current methods are categorized as biochemical (labeled) or physical (label-free), each with limitations.
Integrating multiple isolation principles is a key strategy to overcome individual method drawbacks.

Purpose of the Study:

To review recent advances in microfluidic cell sorting techniques.
To emphasize the mechanisms of cell separation in integrated systems.
To discuss challenges and future perspectives in microfluidic cell sorting.

Main Methods:

Review of microfluidic cell sorting techniques combining physical and biochemical principles.
Introduction to biochemical methods enhanced by physical principles.
Introduction to physical methods enhanced by biochemical principles.

Main Results:

Highlighting on-chip magnetic-activated cell sorting (MACS) and on-chip fluorescence-activated cell sorting (FACS).
Discussion of multi-step and multi-principle cell sorting techniques.
Analysis of integrated systems based on combined separation mechanisms.

Conclusions:

Integrated microfluidic cell sorting shows significant promise for overcoming limitations of single-principle methods.
Combined physical and biochemical approaches enhance cell separation accuracy and efficiency.
Further research into integrated microfluidics is crucial for advancing cell sorting technologies.