Related Experiment Video
Updated: Feb 4, 2026

Measurement of Cyclic Guanosine Monophosphate (cGMP) in Solid Tissues using Competitive Enzyme-Linked Immunosorbent Assay (ELISA)
Published on: July 3, 2025
Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water
Makoto Takenaka1, Mitsuhiro Kikkawa1, Takahiro Matsumoto1
1Department of Chemistry and Biochemistry, Graduate School of Engineering, Center for Small Molecule Energy, International Institute for Carbon-Neutral Energy Research, (WPI-I2CNER), Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.
Abstract:
Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.
Related Concept Videos
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Oxidation Numbers
Oxidation-Reduction Reactions
States of Water
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
Formation of Complex Ions
The Water Cycle

