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The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with

Wenyue Wang1, Xu Li2, Xiuhua Yao3

  • 1Department of Prevention and Health Care.

Medicine
|October 14, 2018
PubMed

Insights

The gut microbiome differs between cerebral infarction (CI) patients and healthy individuals. Gut bacteria may serve as biomarkers for CI, potentially mediated by apolipoprotein E (ApoE).

Area of Science:

  • Microbiology
  • Neurology
  • Gastroenterology

Background:

  • Cerebral infarction (CI) causes significant disability and mortality, particularly in China, with unclear underlying mechanisms.
  • Intestinal microecology is implicated in cardiovascular and cerebrovascular diseases, suggesting a potential role in CI.

Purpose of the Study:

  • To investigate differences in intestinal microecology between CI patients and healthy individuals.
  • To explore the relationship between intestinal flora, apolipoprotein E (ApoE) levels, and CI.

Main Methods:

  • 16S rRNA sequencing was used to analyze the gut microbial composition in fecal samples from 10 CI patients and 10 healthy controls.
  • Microbial diversity and relative abundance were assessed using UPGMA and PCoA.
  • Serum apolipoprotein E (ApoE) levels were measured via ELISA, and correlations with gut flora were analyzed.

Main Results:

  • Significant differences in the structure and diversity of intestinal microecology were observed between CI patients and healthy individuals.
  • CI patients exhibited increased Gammaproteobacteria and decreased Bacteroidia at the class level in their stool.
  • A correlation was identified between serum ApoE levels and the abundance of Bacteroidia and Gammaproteobacteria species.

Conclusions:

  • Intestinal flora composition can serve as a potential indicator for cerebral infarction.
  • The observed alterations in gut microecology may contribute to CI, possibly mediated by the up-regulation of apolipoprotein E.

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