Related Experiment Video
Updated: Feb 4, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
Published on: March 28, 2025
Stress-induced modulation of pain: Role of the endogenous opioid system
Mehnaz Ferdousi1, David P Finn1
1Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland; Centre for Pain Research, NCBES, National University of Ireland Galway, Galway, Ireland; Galway Neuroscience Centre, NCBES, National University of Ireland Galway, Galway, Ireland.
Abstract:
Depending on its nature, duration, and intensity, stress can exert potent and bidirectional modulatory effects on pain, either reducing pain (stress-induced analgesia) or exacerbating it (stress-induced hyperalgesia). The descending pain pathway has been implicated in both stress-induced analgesia and stress-induced hyperalgesia. The endogenous opioid system is widely distributed throughout the descending pain pathway and regulates nociceptive signaling, emotionality, and the response to stress. Here we review the evidence for a key role of the endogenous opioid system in stress-induced modulation of pain in rodents and humans. Understanding the neurobiological mechanisms underlying opioidergic regulation of stress-pain interactions may help in identifying novel therapeutic strategies for the improved treatment of comorbid pain and stress-related disorders.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Receptors: Overview
Opioid Analgesics: Morphine and Other Natural Cogeners
Pain
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.

