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Structural MRI in Idiopathic Parkinson's Disease
Rosa De Micco1, Antonio Russo1, Alessandro Tessitore1
1Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Napoli, Italy; MRI Research Center SUN-FISM, University of Campania "Luigi Vanvitelli", Napoli, Italy.
International Review of Neurobiology
|October 14, 2018
Summary
Magnetic resonance imaging (MRI) aids in diagnosing Parkinson's disease (PD) by detecting brain abnormalities. Structural MRI analysis reveals neurodegeneration and symptoms, offering insights into early disease stages and white/gray matter changes.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Magnetic resonance imaging (MRI) is a key non-invasive tool for neurodegenerative disorder detection.
- MRI is extensively used in Parkinson's disease (PD) research for diagnosis and understanding symptom pathophysiology.
- Structural MRI provides insights into brain morphology and function, crucial for neurodegenerative disease assessment.
Purpose of the Study:
- To analyze the role of structural MRI in differentiating Parkinson's disease (PD) patients from healthy controls.
- To identify the neural substrates underlying motor and non-motor symptoms in PD.
- To critically evaluate evidence from the premotor phase of PD using structural imaging.
Main Methods:
- Review of structural MRI studies focusing on white matter and gray matter integrity in PD.
- Analysis of different analytical approaches to derive brain morphology and function from MRI scans.
- Examination of neuroimaging biomarkers for neurodegeneration and microstructural changes.
Main Results:
- Structural MRI can differentiate PD patients from controls.
- Imaging studies highlight neural substrates associated with PD motor and non-motor symptoms.
- Evidence regarding the premotor phase of PD using structural imaging is critically discussed.
Conclusions:
- Structural MRI is valuable for PD diagnosis and understanding symptom-related neural changes.
- The review highlights the strengths and limitations of structural MRI in clinical applications for PD.
- Further research can refine the application of structural MRI in early PD detection and management.