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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia
Lorena de la Fuente-Tomas1, Mónica Sánchez-Autet2, Leticia García-Álvarez1
1Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM G-05); Departamento de Psiquiatría, Universidad de Oviedo; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, España.
Abstract:
Clinical staging is a diagnostic tool used in other medical specialties, which has resulted from the combination of a categorical and dimensional approach. In the last 2decades, the usefulness of its application in the field of psychiatry has been suggested, mainly as a tool for diagnostic help, and therapeutic and prognostic orientation. In this paper we review the clinical staging models that have been proposed to date for bipolar disorder, depression and schizophrenia. A literature search was performed in PubMed and Medline databases. A total of 15 studies were selected according to inclusion and exclusion criteria. Models were grouped according to the type of disorder for which staging was proposed (bipolar disorder: 4, depression: 5, schizophrenia: 6), and their characteristics were described. As a conclusion, we identify the need to empirically validate these models to demonstrate that staging is a useful tool for clinical practice.
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