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The role of microRNAs in human embryo implantation: a review

Anthea B M Paul1, Seifeldin T Sadek2, Arnold M Mahesan3

  • 1Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.

Journal of Assisted Reproduction and Genetics
|October 14, 2018
PubMed

Insights

MicroRNAs (miRNAs) are crucial for human embryo implantation, influencing blastocyst and endometrial interactions. These molecules show potential as predictive biomarkers for implantation success, despite current research inconsistencies.

Area of Science:

  • Reproductive biology
  • Molecular genetics

Background:

  • Human embryo implantation is a complex process involving blastocyst-endometrium interactions.
  • MicroRNAs (miRNAs) are critical regulators of gene expression with emerging roles in reproductive processes.

Purpose of the Study:

  • To review the literature on microRNAs (miRNAs) in human embryo implantation from a clinical perspective.
  • To explore the potential of miRNAs as biomarkers for predicting implantation success.

Main Methods:

  • Literature review of studies investigating miRNA expression in relation to embryo implantation.
  • Analysis of miRNA differential expression in various implantation-related contexts (blastocyst quality, endometrial receptivity, implantation failure).

Main Results:

  • MicroRNAs (miRNAs) are differentially expressed in implanted vs. non-implanted blastocysts and euploid vs. aneuploid blastocysts.
  • Endometrial miRNA expression varies between proliferative and decidualized states, and receptive vs. pre-receptive phases.
  • Altered miRNA profiles are observed in the endometrium of women with implantation failure and recurrent implantation failure.

Conclusions:

  • MicroRNAs (miRNAs) play a significant role in human embryo implantation.
  • Despite challenges in reproducibility, miRNAs hold promise as clinical biomarkers for predicting embryo implantation success.
Keywords:
EndometriumHuman embryoImplantationMicroRNAPregnancyRecurrent implantation failure

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