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Updated: Feb 4, 2026
11:13
Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
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Abdominal Aortic Aneurysm Pathomechanics: Current Understanding and Future Directions.
Erica M C Kemmerling1, Robert A Peattie2
1Department of Mechanical Engineering, Tufts University, Medford, MA, USA.
Advances in Experimental Medicine and Biology
|October 14, 2018
Summary
Abdominal aortic aneurysms (AAAs) are aortic expansions that can rupture, causing death. Research investigates AAA biology and mechanics to improve rupture risk assessment and patient management.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Pathophysiology
Background:
- Abdominal aortic aneurysms (AAAs) are localized aortic expansions, posing a fatal rupture risk.
- AAAs are prevalent in individuals over 60, contributing to significant mortality in the US.
- AAA rupture is a mechanical event, driving research into its progression and rupture mechanisms.
Purpose of the Study:
- To review the degenerative changes in the aortic wall during AAA pathogenesis.
- To describe current knowledge of hemodynamics, transport, and mechanics within AAAs.
- To identify open research questions and future directions for improved clinical management.
Main Methods:
- Literature review summarizing AAA pathogenesis.
- Analysis of studies on AAA hemodynamics, transport, and biomechanics.
- Discussion of current research gaps and future research avenues.
Main Results:
- Degenerative changes in the aorta wall are central to AAA pathogenesis.
- Hemodynamics, transport phenomena, and wall mechanics play critical roles in AAA progression.
- Understanding these factors is key to developing better clinical risk assessment tools.
Conclusions:
- Further research into AAA biology and mechanics is crucial for improving clinical evaluation.
- Investigating AAA pathophysiology can lead to enhanced patient management strategies.
- Addressing open questions in aneurysm research will advance the field and reduce mortality.
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