Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Tumor Progression02:07

Tumor Progression

7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.7K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stacked human aortic endothelial cells induce atherosclerotic fatty streaks and release proinflammatory cytokines and chemokines.

Mechanobiology in medicine·2026
Same author

A model for solute transport across the arteriole wall.

Journal of biomechanics·2025
Same author

A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood-Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow.

Cells·2025
Same author

Editorial: Glycocalyx in physiology and vascular related diseases-volume II.

Frontiers in cell and developmental biology·2024
Same author

Angiogenesis and Microvascular Permeability.

Cold Spring Harbor perspectives in medicine·2024
Same author

Heparan Sulfate Modulation Affects Breast Cancer Cell Adhesion and Transmigration across In Vitro Blood-Brain Barrier.

Cells·2024
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.2K

Tumor Metastasis in the Microcirculation.

Bingmei M Fu1

  • 1Department of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA. fu@ccny.cuny.edu.

Advances in Experimental Medicine and Biology
|October 14, 2018
PubMed
Summary
This summary is machine-generated.

Understanding tumor cell metastasis is key to fighting cancer mortality. This research explores how blood flow dynamics and vessel interactions influence cancer cell spread, offering insights for new therapies.

More Related Videos

Acellular and Cellular Lung Model to Study Tumor Metastasis
08:31

Acellular and Cellular Lung Model to Study Tumor Metastasis

Published on: August 19, 2018

8.0K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.9K

Related Experiment Videos

Last Updated: Jan 26, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.2K
Acellular and Cellular Lung Model to Study Tumor Metastasis
08:31

Acellular and Cellular Lung Model to Study Tumor Metastasis

Published on: August 19, 2018

8.0K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.9K

Area of Science:

  • Oncology
  • Biophysics
  • Cell Biology

Background:

  • Metastasis, responsible for ~90% of cancer deaths, involves tumor cells spreading via blood circulation.
  • The microvessel wall, comprising vascular endothelium and glycocalyx, regulates transport and is a site for tumor cell extravasation.
  • Tumor cell adhesion and extravasation occur at the cleft between endothelial cells, influenced by blood flow dynamics.

Purpose of the Study:

  • To review current research on tumor cell metastasis in microcirculation.
  • To elucidate the roles of endothelial integrity, hydrodynamic factors, microvascular geometry, cell adhesion molecules, and extracellular matrix in metastasis.
  • To highlight advances from in vivo and in vitro studies.

Main Methods:

  • Review of in vivo animal studies on tumor metastasis.
  • Analysis of in vitro cell culture studies.
  • Examination of factors influencing tumor cell arrest, adhesion, and extravasation.

Main Results:

  • Blood flow dynamics (shear rates, stresses, gradients, vorticities) significantly impact tumor cell arrest and adhesion, especially at microvascular bifurcations.
  • Endothelial integrity, microvascular permeability, and geometry are critical regulators of tumor cell extravasation.
  • Cell adhesion molecules and the extracellular matrix play crucial roles in mediating tumor cell interactions with the microvasculature.

Conclusions:

  • Understanding the interplay between tumor cells and the microcirculation is vital for developing anti-metastasis strategies.
  • Targeting hydrodynamic factors, endothelial interactions, and cell adhesion mechanisms presents potential therapeutic avenues.
  • Further research integrating in vivo and in vitro findings can advance cancer treatment by inhibiting metastatic spread.