Professor Lev Beloussov and the birth of morphomechanics

The first explanations of the mechanisms of development of living organisms were proposed in antiquity. At that time two competing ideas existed, about the strict determination of embryonic structures (we call it the "Hippocrates line") and about the possible formation of structures from the unstructured condition ("Aristotle line"). We can trace the opposition between the "Hippocrates line" and "Aristotle line" from antiquity till the present time. At the end of the XIX century, experimental investigation of the mechanisms of integrity of development had started. In the XX century, the "Aristotle line" finds its expression in the Morphogenetic Field Theory of A.G. Gurwitsch, according to which cells of the organism are integrated in an organic whole. Since the 1970s, mechanical forces and tensions have been considered as integral factors of ontogenesis. One of the most productive scientific teams which worked in this area was the laboratory of Professor L.V. Beloussov from the Lomonossov Moscow State University, Russia. In the 1970s, Lev Beloussov and his colleagues discovered the presence of "passive" and "active" (i.e. metabolically-dependent) mechanical stresses in the tissues of developing organisms, their organization and stage-specific patterns. In 1980-1990 s, a lot of experimental data about the role of the patterns of mechanical stresses in morphogenesis and cell differentiation was accumulated. Based on the experimental data, Professor Beloussov and his colleagues developed a theory of the regulation of the development of living organisms on the basis of the interaction of passive and active mechanical stresses (Belousov-Mittenthal Theory), which forms the basis of a new science - morphomechanics.