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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
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Thermoresponsive polymer nanocarriers for biomedical applications
Alexandre Bordat1, Tanguy Boissenot1, Julien Nicolas1
1Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Advanced Drug Delivery Reviews
|October 14, 2018
Summary
Thermoresponsive polymers offer controlled drug release via nanocarriers. Both lower critical solution temperature (LCST) and upper critical solution temperature (UCST) polymers show promise for advanced drug delivery systems.
Area of Science:
- Biomedical Engineering
- Materials Science
- Polymer Chemistry
Background:
- Polymer nanocarriers protect fragile drugs, enhance solubility, and prolong half-life.
- Controlling drug release from nanocarriers remains a significant challenge in drug delivery.
- Thermoresponsive polymers, with LCST or UCST, offer potential for controlled release.
Purpose of the Study:
- To review the use of LCST and UCST polymers in thermoresponsive nanocarriers for biomedical applications.
- To highlight recent advancements in thermoresponsive nanocarriers for drug delivery.
- To compare the potential of LCST and UCST polymers in drug release applications.
Main Methods:
- Literature review of thermoresponsive polymers (LCST and UCST).
- Analysis of nanocarrier systems utilizing these polymers.
- Discussion of applications in drug delivery and biomedical fields.
Main Results:
- LCST nanocarriers have been extensively studied for over 20 years.
- UCST nanocarriers are a recent development showing significant potential.
- Both polymer types enable spatially and temporally controlled drug release.
Conclusions:
- Thermoresponsive polymers are key to developing advanced drug delivery systems.
- UCST polymers represent a promising new frontier for thermoresponsive drug release.
- Further research into UCST nanocarriers could lead to improved therapeutic outcomes.
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