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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
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Model testing for distinctive functional connectivity gradients with resting-state fMRI data.

Jonathan F O'Rawe1, Jaime S Ide2, Hoi-Chung Leung1

  • 1Integrative Neuroscience Program, Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA.

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|October 14, 2018
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Summary
This summary is machine-generated.

Functional connectivity gradients in the human striatum differ between the caudate and putamen, challenging previous assumptions of uniform organization. This study reveals distinct topographic patterns, including a medial-lateral gradient within the caudate.

Keywords:
Functional gradientResting-state fMRIStriatal organization

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Area of Science:

  • Neuroimaging
  • Neuroanatomy
  • Computational Neuroscience

Background:

  • Resting-state fMRI (functional Magnetic Resonance Imaging) is used to study functional connectivity gradients.
  • Topographic organization is assumed to be uniform across brain regions.
  • The striatum, comprising the caudate nucleus and putamen, is studied for its connectivity patterns.

Purpose of the Study:

  • To develop and test a statistical model for evaluating differences in functional connectivity gradients across brain structure subdivisions.
  • To assess the assumption of uniform functional organization within the striatum.
  • To investigate species-specific differences in striatal functional topography.

Main Methods:

  • Developed a statistical model testing procedure to differentiate between overlapping, shifted, or distinct topographic connectivity gradients.
  • Applied the procedure to human and macaque resting-state fMRI data of the striatum.
  • Validated the model selection procedure using checkerboard subdivisions as controls.

Main Results:

  • Models with distinct functional connectivity gradients for the caudate and putamen were preferred over a single gradient model in human and macaque data.
  • A diagonal gradient organization was replicated in both the caudate and putamen.
  • A medial-lateral organization was identified within the caudate, which was obscured when assuming a single gradient.

Conclusions:

  • The assumption of uniform functional connectivity gradients across the striatum is not supported.
  • Differential topographic gradients exist between the caudate and putamen.
  • A medial-lateral gradient within the human caudate nucleus is a significant finding requiring further investigation.