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Changes in bone matrix properties with aging.

David B Burr1

  • 1Dept. of Anatomy and Cell Biology, Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, United States of America; Dept. of Biomedical Engineering, Indiana University-Purdue University, Indianapolis (IUPUI), United States of America.

Bone
|October 14, 2018
PubMed
Summary
This summary is machine-generated.

Aging bone tissue undergoes significant matrix changes, including alterations in mineral content, collagen cross-linking, and water distribution. These age-related shifts in bone quality, not just bone mass, increase skeletal fragility in older adults.

Keywords:
BiomechanicsBone waterCollagenCross-linkingMineralNoncollagenous proteins

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Area of Science:

  • Bone biology and aging research.
  • Skeletal biomechanics and tissue engineering.

Background:

  • Bone loss with aging is a known contributor to skeletal fragility.
  • Age-related changes in bone tissue quality, beyond mass, are less understood.
  • These quality changes exacerbate fragility in the elderly population.

Purpose of the Study:

  • To explore age-related alterations in the bone tissue matrix.
  • To understand how these matrix changes contribute to skeletal fragility.

Main Methods:

  • Review of existing literature on bone aging.
  • Analysis of age-dependent changes in bone mineral, collagen, water, and non-collagenous proteins.

Main Results:

  • Bone quality is impacted by changes in mineral crystals, collagen cross-linking (enzymatic and non-enzymatic), and water compartments.
  • Increased non-enzymatic collagen cross-links contribute to bone brittleness.
  • Altered water content reduces the bone's capacity to deform before fracture.

Conclusions:

  • Age-related changes in bone matrix composition and structure significantly contribute to skeletal fragility.
  • Further investigation is needed to fully elucidate the roles of non-collagenous proteins and other factors.
  • Current clinical methods are insufficient to assess these critical age-related bone quality changes.