Related Experiment Video

Updated: Feb 4, 2026

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors
08:50

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors

Published on: July 16, 2018

8.7K

The Risk Factors of mTORi-Associated Posttransplant Proteinuria

L M Lim1, L-F Kung2, M-C Kuo3

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Transplantation Proceedings
|October 15, 2018
PubMed

Insights

Mammalian target of rapamycin inhibitors (mTORi) can increase proteinuria in kidney transplant recipients. Hyperlipidemia and obesity are key risk factors for this side effect, aiding in patient selection for mTORi therapy.

Area of Science:

  • Nephrology
  • Immunosuppression
  • Transplantation Medicine

Background:

  • Mammalian target of rapamycin inhibitors (mTORi) are used as immunosuppressants post-kidney transplantation.
  • Increased incidence of proteinuria is noted with mTORi compared to other immunosuppressants.
  • The exact mechanisms and risk factors for mTORi-associated proteinuria remain unclear.

Purpose of the Study:

  • To investigate the risk factors associated with proteinuria in kidney transplant recipients treated with mTOR inhibitors.
  • To identify predictors of proteinuria to optimize patient selection and outcomes.

Main Methods:

  • Retrospective observational study of kidney transplant recipients.
  • Data collected from January 1999 to April 2016 in Southern Taiwan.
  • Multivariate logistic regression analysis used to examine risk factors for mTORi-associated proteinuria.

Main Results:

  • Hyperlipidemia was identified as a significant predictor of proteinuria.
  • Obesity at the initiation of mTORi treatment was also a strong predictor.
  • Statistically significant findings were determined with P < .05.

Conclusions:

  • Hyperlipidemia and obesity are significant risk factors for proteinuria in kidney transplant recipients on mTOR inhibitors.
  • Early identification of these risk factors can guide physicians in mTORi conversion decisions.
  • Optimizing transplantation outcomes may be achieved by considering these risk factors.

More Related Videos

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.7K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.0K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.1K
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.9K
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
985