The Risk Factors of mTORi-Associated Posttransplant Proteinuria.

Area of Science:

• Nephrology
• Immunosuppression
• Transplantation Medicine

Background:

• Mammalian target of rapamycin inhibitors (mTORi) are used as immunosuppressants post-kidney transplantation.
• Increased incidence of proteinuria is noted with mTORi compared to other immunosuppressants.
• The exact mechanisms and risk factors for mTORi-associated proteinuria remain unclear.

Purpose of the Study:

• To investigate the risk factors associated with proteinuria in kidney transplant recipients treated with mTOR inhibitors.
• To identify predictors of proteinuria to optimize patient selection and outcomes.

Main Methods:

• Retrospective observational study of kidney transplant recipients.
• Data collected from January 1999 to April 2016 in Southern Taiwan.
• Multivariate logistic regression analysis used to examine risk factors for mTORi-associated proteinuria.

Main Results:

• Hyperlipidemia was identified as a significant predictor of proteinuria.
• Obesity at the initiation of mTORi treatment was also a strong predictor.
• Statistically significant findings were determined with P < .05.

Conclusions:

• Hyperlipidemia and obesity are significant risk factors for proteinuria in kidney transplant recipients on mTOR inhibitors.
• Early identification of these risk factors can guide physicians in mTORi conversion decisions.
• Optimizing transplantation outcomes may be achieved by considering these risk factors.