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Mouse Kidney Transplantation: Models of Allograft Rejection
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Severe Phlebitis Accompanying Vascular Rejection Type Acute T Cell-Mediated Rejection in Renal Transplantation

K Yamanaka1, K Oka2, T Abe3

  • 1Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan.

Transplantation Proceedings
|October 15, 2018
PubMed
Abstract

Insights

Severe phlebitis, characterized by inflammatory cells in veins, is a novel finding linked to vascular rejection in kidney transplant patients. This marker may aid in understanding poor prognosis in acute T cell-mediated rejection (ATCMR) grade II.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Pathology

Background:

  • Acute T cell-mediated rejection (ATCMR) grade II in renal transplant recipients is associated with a poor prognosis.
  • Vascular lesions in ATCMR are often considered randomly distributed, necessitating the search for novel pathological markers.

Purpose of the Study:

  • To identify a novel pathological marker associated with vascular rejection in kidney transplantation.
  • To investigate the characteristics of vascular lesions in ATCMR grade II patients.

Main Methods:

  • Pathological characteristics of 14 ATCMR grade II patients were analyzed.
  • Transplant kidney biopsy specimens from patients without vascular rejection were examined for specific findings.

Main Results:

  • Phlebitis with inflammatory cell projections and endothelial damage was observed in 9 of 14 ATCMR grade II patients.
  • Phlebitis was significantly more frequent in vascular rejection cases compared to other findings.
  • No significant difference in graft survival was found between patients with and without phlebitis.

Conclusions:

  • Severe phlebitis is identified as a novel pathological finding associated with vascular rejection in renal allografts.
  • This finding may contribute to understanding the pathology of vascular rejection in kidney transplantation.

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