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Opioid dispensing patterns after oocyte retrieval.

Pietro Bortoletto1, Malavika Prabhu2, Elizabeth M Garry3

  • 1Department of Obstetrics, Gynecology & Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.

Fertility and Sterility
|October 15, 2018
PubMed
Summary
This summary is machine-generated.

Opioid dispensing after oocyte retrieval is infrequent but varies significantly. Women with mood disorders or on antidepressants were more likely to receive opioid prescriptions.

Keywords:
Oocyte retrievalopioidspain

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Area of Science:

  • Reproductive endocrinology and infertility
  • Pain management and pharmacology
  • Public health and pharmacoepidemiology

Background:

  • Oocyte retrieval is a key procedure in assisted reproductive technologies.
  • Understanding post-procedural medication patterns, particularly opioid use, is crucial for patient care and safety.
  • Limited data exists on opioid dispensing trends following oocyte retrieval.

Purpose of the Study:

  • To investigate the patterns of opioid dispensing in women undergoing oocyte retrieval.
  • To identify the frequency, types, and quantities of opioids prescribed post-procedure.
  • To examine patient characteristics associated with opioid prescription filling.

Main Methods:

  • A retrospective cohort study analyzed data from 61,463 women undergoing oocyte retrieval.
  • Opioid dispensing within three days of the procedure was assessed.
  • Multivariate regression analyses identified factors associated with opioid prescription filling.

Main Results:

  • 11.9% of women received an opioid prescription post-oocyte retrieval.
  • Hydrocodone, codeine, and oxycodone were the most commonly dispensed opioids.
  • Women with mood disorders, tobacco use, or antidepressant use showed increased likelihood of opioid dispensing.

Conclusions:

  • While opioid use after oocyte retrieval is relatively low, significant variability exists in dispensed amounts.
  • Specific patient comorbidities and concurrent medications are associated with higher rates of opioid prescription filling.
  • These findings highlight the need for judicious opioid prescribing and patient monitoring in this population.