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Related Experiment Video

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Selective Harvesting of Marginating-pulmonary Leukocytes
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Terrien marginal degeneration.

Yanning Ding1, Michael S Murri2, Orry C Birdsong1

  • 1HDR Research Center, Hoopes Vision, Draper, UT, United States.

Survey of Ophthalmology
|October 15, 2018
PubMed
Summary
This summary is machine-generated.

Terrien marginal degeneration is a rare peripheral corneal thinning condition affecting middle-aged males, causing vision loss due to astigmatism. Early diagnosis and appropriate management, from contact lenses to surgery, are crucial for preserving sight.

Keywords:
RGP contact lensesTMDTerrien's marginal degenerationastigmatismin vivo confocal microscopylamellar keratoplastyoptical coherence tomographyscleral lenses

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Area of Science:

  • Ophthalmology
  • Corneal Diseases

Background:

  • Terrien marginal degeneration is a rare peripheral corneal thinning disease.
  • It typically affects middle-aged males, leading to decreased visual acuity and increased corneal astigmatism.
  • The exact etiology remains unknown, with suspected degenerative and inflammatory origins.

Purpose of the Study:

  • To summarize the key aspects of Terrien marginal degeneration.
  • To highlight diagnostic considerations and management options.

Main Methods:

  • Review of histopathologic findings, noting intracellular and extracellular vacuoles in the corneal stroma.
  • Comparison with other peripheral corneal diseases like Mooren ulcer and pellucid marginal degeneration.
  • Outline of current and potential treatment strategies.

Main Results:

  • Clinical presentation includes peripheral corneal thinning and irregular astigmatism.
  • Histopathology reveals characteristic stromal vacuoles.
  • Differential diagnosis from similar peripheral corneal conditions is essential.

Conclusions:

  • Terrien marginal degeneration requires careful diagnosis and management.
  • Nonsurgical options include visual aids and specialized contact lenses.
  • Surgical intervention, such as keratoplasty, is indicated for significant thinning (≤150 μm).