Related Experiment Video
Updated: Feb 4, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Host-based processes as therapeutic targets for Rift Valley fever virus
Chelsea Pinkham1, Aslaa Ahmed1, Nicole Bracci1
1National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, USA.
Abstract:
Rift Valley fever virus (RVFV) is an enveloped, segmented, negative sense RNA virus that replicates within the host's cytoplasm. To facilitate its replication, RVFV must utilize host cell processes and as such, these processes may serve as potential therapeutic targets. This review summarizes key host cell processes impacted by RVFV infection. Specifically the influence of RVFV on host transcriptional regulation, post-transcriptional regulation, protein half-life and availability, host signal transduction, trafficking and secretory pathways, cytoskeletal modulation, and mitochondrial processes and oxidative stress are discussed. Therapeutics targeted towards host processes that are essential for RVFV to thrive as well as their efficacy and importance to viral pathogenesis are highlighted.
Related Concept Videos
What are Viruses?
Types of Fever
Here are the different types of fever:
Patterns of Fever
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Cardiovascular Drugs: Classification based on Therapeutic Indications
Therapeutic Index

