Effector variation at tandem gene arrays in tissue-dwelling coccidia: who needs antigenic variation anyway?
Matthew L Blank1, Jon P Boyle1
1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abstract:
Locus expansion and diversification is pervasive in apicomplexan genomes and is predominantly found in loci encoding secreted proteins that interact with factors outside of the parasite. Key for understanding the impact of each of these loci on the host requires identification and functional characterization of their protein products, but these repetitive loci often are refractory to genome assembly. In this review we focus on Toxoplasma gondii and its nearest relatives to highlight the known impact of duplicated and diversified loci on our understanding of the host-pathogen molecular arms race. We describe current tools used for the identification and characterization of these loci, and review the most recent examples of how gene-expansion driven diversification can lead to novel gene functions.
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