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Methicillin-sensible Staphylococcus aureus causing endocarditis, with cerebral and orthopaedic complications, in a

Guillaume Geslain1,2, Clara Bourgade3, Maryline Chomton1

  • 1Paediatric Mobile Emergency and Intensive Care Units, Hopital Universitaire Robert-Debre, Paris, France.

BMJ Case Reports
|October 15, 2018
PubMed

Insights

This case study details a 17-month-old infant with Staphylococcus aureus endocarditis, complicated by meningitis and strokes. Successful valve replacement led to a favorable outcome, highlighting a rare presentation in a young child.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Neurology

Background:

  • Staphylococcus aureus endocarditis is rare in infants without risk factors.
  • Complex clinical presentations can arise from infective endocarditis in children.

Observation:

  • A 17-month-old infant presented with Staphylococcus aureus endocarditis and large vegetation.
  • Complications included meningitis, ischemic strokes, and osteoarthritis, progressing to a hemorrhagic stroke due to aneurysm rupture.

Findings:

  • The Staphylococcus aureus strain was methicillin-susceptible and belonged to clonal complex 398 with accessory gene regulator I.
  • No underlying immunodeficiency was identified in the patient.

Implications:

  • Early diagnosis and aggressive management, including valve replacement, are crucial for favorable outcomes in pediatric infective endocarditis.
  • This case underscores the potential for severe neurological and systemic complications even in the absence of typical risk factors.
Keywords:
Bone And Joint InfectionsInfectious DiseasesPaediatricsStroke

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