Swept-source OCT in patients with multiple evanescent white dot syndrome

Area of Science:

• Ophthalmology
• Medical Imaging

Background:

• Multiple evanescent white dot syndrome (MEWDS) is an inflammatory condition affecting the retina.
• Swept-source optical coherence tomography (SS-OCT) offers advantages over spectral-domain OCT (SD-OCT) for retinal imaging.

Purpose of the Study:

• To describe and correlate imaging features of MEWDS using fundus autofluorescence (FAF), en-face SS-OCT, and SS-OCT angiography (OCTA).
• To evaluate the utility of SS-OCT in visualizing retinal vascular plexuses and choriocapillaris in MEWDS.

Main Methods:

• Two patients diagnosed with MEWDS underwent FAF, en-face SS-OCT, and SS-OCTA.
• Imaging findings were analyzed and correlated with clinical presentation.

Main Results:

• Clinical and imaging findings confirmed MEWDS diagnosis.
• Subtle deep retinal white spots and hyperautofluorescent lesions were observed.
• SS-OCT showed ellipsoid zone disruption; en-face SS-OCT revealed corresponding outer retinal attenuation.
• SS-OCT angiography demonstrated preserved flow in retinal vasculature and choriocapillaris.

Conclusions:

• SS-OCT provides enhanced visualization of the choriocapillaris.
• Normal choriocapillaris appearance in MEWDS suggests primary inflammation in the outer retina and photoreceptors.