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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal

Patrick Schuss¹, Alexis Hadjiathanasiou², Simon Brandecker²

¹Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany. patrick.schuss@ukbonn.de.

Journal of Neurology

|October 15, 2018

Introduction:

Patients with non-aneurysmal subarachnoid hemorrhage (SAH) are considered to have an overall benign course of disease compared to patients suffering from aneurysmal SAH. Nevertheless, a small but significant number of such patients might only achieve unfavorable outcome. Therefore, the purpose of the present study was to determine if routine laboratory markers of acute phase response are associated with unfavorable outcome in patients with non-aneurysmal SAH.

Methods:

From 2006 to 2017, 154 patients suffering from non-aneurysmal SAH were admitted to our institution. Patients were stratified according to the distribution of cisternal blood into patients with perimesencephalic SAH (pSAH) versus non-perimesencephalic SAH (npSAH). C-reactive protein (CRP) and white blood cells (WBC) assessments were performed within 24 h of admission as part of routine laboratory workup. Outcome was assessed according to the modified Rankin Scale (mRS) after 6 months and stratified into favorable (mRS 0-2) vs. unfavorable (mRS 3-6).

Results:

The multivariate regression analysis revealed "CRP > 5 mg/l" (p = 0.004, OR 143.7), "WBC count > 12.1 G/l" (p = 0.006, OR 47.8), "presence of IVH" (p = 0.02, OR 13.5), "poor-grade SAH" (p = 0.01, OR 45.2) and "presence of CVS" (p = 0.003, OR 149.9) as independently associated with unfavorable outcome in patients with non-aneurysmal SAH.

Conclusion:

Elevated C-reactive protein and WBC count at admission were associated with unfavorable outcome after non-aneurysmal SAH.

Keywords:

C-reactive protein Non-aneurysmal subarachnoid hemorrhage Outcome Perimesencephalic

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The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

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