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Area of Science:

  • Neurology
  • Health Services Research
  • Patient Education

Background:

  • People with multiple sclerosis (MS) face significant uncertainties regarding diagnosis, prognosis, and treatment.
  • Effective communication and information provision are crucial for informed decision-making and self-management in MS care.
  • Existing research indicates deficits in information and decision support for individuals with MS.

Purpose of the Study:

  • To evaluate the effectiveness of information provision interventions for people with MS.
  • To assess the impact on informed choice and patient-relevant outcomes.
  • To analyze intervention components, developmental processes, evidence certainty, and future research needs.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs), cluster-RCTs, and quasi-RCTs.
  • Searched multiple databases including Cochrane MS Register, CENTRAL, MEDLINE, Embase, CINAHL, LILACS, and PEDro.
  • Independent assessment of study relevance, methodological quality, and data extraction by two reviewers.

Main Results:

  • Eleven RCTs involving 1387 participants were analyzed, with interventions covering various MS topics and utilizing diverse approaches.
  • Information provision interventions significantly increased MS-related knowledge (moderate-certainty evidence).
  • Results for decision-making and quality of life were mixed (low-certainty evidence), with no reported adverse events.

Conclusions:

  • Information provision appears to improve disease-related knowledge in people with MS.
  • The effects on decision-making and quality of life are less conclusive.
  • Heterogeneity in interventions and outcomes presents challenges for interpretation; further research is warranted.