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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
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Update on pathological platelet activation in coronary thrombosis.
Edoardo Elia1, Fabrizio Montecucco1,2,3, Piero Portincasa4
1Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Genoa, Italy.
Journal of Cellular Physiology
|October 15, 2018
Summary
Coronary thrombosis (CT) involves complex platelet (PLT) activation pathways, including lipid oxidation and cell interactions. Emerging research reveals novel PLT roles in signaling and gene regulation, impacting cardiovascular outcomes.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Immunology
Background:
- Coronary thrombosis (CT) is critical for cardiovascular events, but its mechanisms are not fully understood.
- Platelet (PLT) activation is central to atherothrombosis, influenced by endothelial dysfunction, oxidized lipoproteins, and immune responses.
Purpose of the Study:
- To review recent advances in coronary thrombosis (CT) and intracoronary stent thrombosis.
- To explore emerging pathophysiological mechanisms and their clinical translation.
Main Methods:
- This narrative review synthesizes current research on CT and stent thrombosis.
- It examines novel platelet activities and intercellular signaling pathways.
Main Results:
- Platelet (PLT) lipidome oxidation enhances PLT reactivity, coagulation, and inflammation.
- Interactions involving neutrophil extracellular traps, NLRP3 inflammasome, and microvesicles (MVs) are key.
- Noncoding RNAs in PLT MVs regulate recipient cell gene expression.
Conclusions:
- Platelets (PLTs) have multifaceted roles beyond hemostasis, significantly impacting coronary thrombosis (CT).
- Understanding these complex mechanisms, including microvesicle-mediated signaling, is crucial for clinical translation and improved cardiovascular outcomes.
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