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Intra-cortical myelin mediates personality differences.

Nicola Toschi1,2, Luca Passamonti3,4

  • 1Department of Biomedicine & Prevention, University "Tor Vergata", Rome, Italy.

Journal of Personality
|October 15, 2018
PubMed
Summary
This summary is machine-generated.

Brain myelin differences are linked to personality traits. Higher myelin in certain areas correlates with traits like conscientiousness and extraversion, offering insights into behavioral variability.

Keywords:
Big-FiveT1/T2-weighted ratioindividual differencesmyelinmyelination

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Behavioral Genetics

Background:

  • Myelination in the cortical mantle influences cognitive, emotional, and behavioral variability.
  • Previous research links personality traits to neuroanatomical and functional brain changes, particularly in prefrontal and temporo-parietal regions.
  • The role of intra-cortical myelin in mediating these personality-brain relationships is not yet fully understood.

Purpose of the Study:

  • To investigate the relationship between intra-cortical myelin and the five-factor model of personality traits.
  • To determine if intra-cortical myelin mediates the association between personality and brain structure.
  • To explore the neurobiological underpinnings of individual differences in behavior.

Main Methods:

  • Utilized vertex-wise intra-cortical myelin maps from 1,003 participants in the Human Connectome Project.
  • Employed multivariate regression analyses to examine associations between myelin and personality traits.
  • Controlled for covariates including age, sex, intelligence quotient, total intracranial volume, and other personality traits.

Main Results:

  • Neuroticism showed inverse relationships with frontal-pole myelin and positive associations with occipital cortex myelin.
  • Extraversion was positively linked to superior parietal myelin.
  • Openness correlated negatively with anterior cingulate myelin; Agreeableness positively with orbitofrontal myelin; Conscientiousness positively with frontal-pole myelin and negatively with dorsal anterior cingulate cortex myelin.

Conclusions:

  • Intra-cortical myelin levels in brain regions with extended myelination are positively associated with personality traits linked to favorable outcomes.
  • These findings enhance understanding of the neurobiological basis for variations in common behavioral dispositions.
  • The study highlights the significance of myelin in shaping personality and behavior.