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Updated: Feb 4, 2026
06:02
Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
Published on: January 31, 2016
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[Gastrointestinal inflammatory myofibroblastic tumor: a clinicopathologic study]
1Department of Pathology, Taizhou Hospital, Zhejiang Province, Taizhou 317000, China.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|October 15, 2018
Summary
Gastrointestinal inflammatory myofibroblastic tumors are rare and often misdiagnosed. Surgical removal is effective, and anaplastic lymphoma kinase (ALK) may represent a new therapeutic target.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gastrointestinal inflammatory myofibroblastic tumor (GI-IMT) is a rare neoplasm.
- GI-IMT can be challenging to diagnose due to its varied presentation.
Purpose of the Study:
- To investigate the clinicopathologic features of GI-IMT.
- To analyze the immunophenotype and anaplastic lymphoma kinase (ALK) gene alterations in GI-IMT.
Main Methods:
- Retrospective analysis of 7 GI-IMT cases from January 2005 to December 2016.
- Histological examination, immunohistochemistry, and ALK fluorescence in situ hybridization (FISH).
Main Results:
- Tumors occurred in the stomach, colon, and rectum in patients aged 1-72 years.
- Histology showed spindle cells with inflammatory infiltrate; immunohistochemistry revealed positivity for vimentin and SMA.
- Two cases showed ALK protein expression and ALK gene rearrangement via FISH.
Conclusions:
- GI-IMT is a rare entity prone to misdiagnosis.
- Surgical resection is a reliable treatment for GI-IMT.
- ALK alterations suggest ALK could be a therapeutic target for GI-IMT.
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