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Related Concept Videos

Curing of Concrete01:20

Curing of Concrete

369
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
369
Curing Methods01:26

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Marcia's Theory of Identity Status01:26

Marcia's Theory of Identity Status

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James Marcia's identity status model provides a framework for understanding how adolescents navigate identity formation through varying degrees of exploration and commitment. Marcia's model builds on Erik Erikson's theories of psychosocial development, focusing specifically on how adolescents reconcile individual aspirations with societal expectations. His model describes identity formation as a dynamic process where adolescents move between different states depending on their level...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Articles linked to this work by shared authors, journal, and citation graph.

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[The partial cure represents an intermediate endpoint on the path to a functional cure, not an ideal endpoint].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2025
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[Introduction to the update points of the 2025 European Association for the Study of Liver clinical practice guidelines for the management of chronic hepatitis B infection].

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[Introduction of the key update points of the 2025 Canadian Association for the Study of the Liver guideline for the management of chronic hepatitis B].

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Prediction of raw meat texture and myopathic severity of broiler breast meat with the wooden breast condition by hyperspectral imaging.

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[Chronic hepatitis B: from "treat only if" to "treat all"].

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Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
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[Status and progress in chronic hepatitis B cure].

H Zhuang1

  • 1Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|October 15, 2018
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Summary

Current hepatitis B treatments require lifelong therapy. New antiviral and immune therapies offer hope for a complete cure for chronic hepatitis B patients.

Keywords:
Complete sterilizing cureFunctional cureHepatitis B virusPartial cure

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Area of Science:

  • Hepatology and Virology
  • Infectious Diseases
  • Immunology

Background:

  • Chronic hepatitis B virus (HBV) infection affects millions globally.
  • Existing antiviral therapies necessitate long-term or lifelong treatment, failing to achieve complete viral eradication for most patients.
  • The need for curative strategies is paramount to reduce long-term complications such as liver cirrhosis and hepatocellular carcinoma.

Purpose of the Study:

  • To review the current landscape of chronic hepatitis B treatment.
  • To summarize recent advancements in antiviral inhibitors and immunomodulatory therapies.
  • To discuss the potential for achieving a functional cure for chronic hepatitis B.

Main Methods:

  • Literature review of recent clinical trials and research publications.
  • Analysis of emerging therapeutic targets and drug development pipelines.
  • Synthesis of data on novel antiviral agents and immune-based strategies.

Main Results:

  • Several new antiviral inhibitors are demonstrating improved efficacy in clinical trials.
  • Immunomodulatory therapies, including therapeutic vaccines and checkpoint inhibitors, show promise in restoring immune control.
  • Combination therapies are being explored to enhance viral clearance and achieve sustained off-treatment responses.

Conclusions:

  • The development of novel antiviral and immune-based therapies is rapidly advancing the field.
  • Achieving a functional cure for chronic hepatitis B is becoming an attainable goal.
  • Continued research and clinical investigation are crucial to translate these advancements into widespread clinical practice.