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Updated: Feb 4, 2026

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
Published on: July 6, 2022
Formation of multilayer through layer-by-layer assembly of starch-based polyanion with divalent metal ion
Juan Liu1, Yinghao Fu1, Congming Xiao1
1College of Material Science and Engineering of Huaqiao University, Quanzhou, 362021, China.
Abstract:
The layer-by-layer (LbL) assembly between metal ion and starch-based anion driven by electrostatic interaction was investigated. Multilayer films were obtained from starch-based derivative containing carboxyl groups (SC) with copper or lead ions. It was found that the concentration of metal ion in aqueous solution decreased with increasing the layers. X-ray photoelectron spectroscopy exhibited the content of Cu(II) was higher when the surface was copper-ion-layer than that composed of SC. The surface of the film was smooth and no obvious fault plane was observed on its cross-section, which also indicated that the LbL assembly between starch-based polyanion and metal ion was carried out. Sodium alginate was adopted as another polyanion to conduct the LbL assembly. Part of metal ion was replaced with rhodamine B to fabricate composite multilayer. During such an assembly, the concentration of copper ion in aqueous solution decreased with increasing the layers as well. These phenomena suggested that the LbL assembly between polysaccharide-based polyanion and metal ion was feasible.
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