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Intermingled Ensembles in Visual Association Cortex Encode Stimulus Identity or Predicted Outcome.

Rohan N Ramesh¹, Christian R Burgess², Arthur U Sugden³

¹Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA.

|October 16, 2018

Summary

This summary is machine-generated.

Neurons in the visual cortex can track predicted outcomes or stimulus features. This study reveals distinct neuronal ensembles encoding either "value" or stimulus identity, suggesting a division of labor.

Keywords:

cortical ensembles food cue long-term imaging mouse postrhinal cortex noise correlations predicted value reversal learning reward history two-photon calcium imaging visual association cortex

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Area of Science:

Neuroscience
Cognitive Neuroscience
Visual Processing

Background:

Cortical neuron responses to visual stimuli can reflect outcome prediction or feature sensitivity.
Distinguishing between these response types is crucial for understanding neural computation.

Purpose of the Study:

To investigate whether visual responses in lateral visual association cortex neurons encode predicted outcomes or stimulus features.
To determine if neuronal ensembles exhibit a division of labor in representing value versus stimulus identity.

Main Methods:

Monitoring neuronal responses in the lateral visual association cortex over weeks.
Presenting visual stimuli with reassigned outcomes before and after learning.
Analyzing neuronal ensemble activity for correlations with predicted outcome, stimulus orientation, or new learning.

Main Results:

Identified correlated neuronal ensembles with responses tracking predicted outcomes, stimulus orientation, or new learning.
Outcome-tracking neurons encoded 'value,' showing bias to food cues and sensitivity to reward history and hunger.
Neurons tracking stimulus orientation lacked these 'value'-related attributes.

Conclusions:

Suggests a division of labor within intermingled ensembles in the visual association cortex.
One set of ensembles encodes predicted value, while another encodes stimulus identity.