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Related Experiment Video

Updated: Feb 4, 2026

Characterizing Cellular Proteins with In-cell Fast Photochemical Oxidation of Proteins

Characterizing Cellular Proteins with In-cell Fast Photochemical Oxidation of Proteins

Published on: March 11, 2020

Dark Proteins Important for Cellular Function.

Andrea Schafferhans^1,2, Seán I O'Donoghue^3,4,5, Michael Heinzinger¹

¹Department of Informatics, Bioinformatics & Computational Biology - i12, TUM (Technical University of Munich), Boltzmannstr. 3, 85748 Garching, Germany.

|October 16, 2018

Summary

This summary is machine-generated.

Many "dark proteins" with unknown structures are highly expressed, suggesting they are crucial for cellular function. This challenges previous assumptions and highlights a key area for future research in structural biology.

Keywords:

dark proteins dark proteome protein expression

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Area of Science:

Structural biology
Proteomics
Genomics

Background:

Many proteins lack known experimental structures or homology models, termed "dark proteins."
Previous hypotheses suggested dark proteins are less expressed than "non-dark proteins" with known structures.

Purpose of the Study:

To investigate the expression levels of dark proteins compared to non-dark proteins.
To assess the functional importance of dark proteins based on their expression.

Main Methods:

Analysis of mRNA abundance.
Analysis of protein abundance.

Main Results:

Human dark and non-dark proteins exhibit similar expression levels.
High expression observed for dark proteins, contrary to prior hypotheses.

Conclusions:

Dark proteins, as a group, are significantly important for cellular function.
The high expression of dark proteins presents a notable challenge for future structural biology research.