Related Experiment Video

Updated: Feb 4, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

Animal models of multiple sclerosis: From rodents to zebrafish

David John Burrows1, Alexander McGown1, Saurabh A Jain1

  • 1Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 16, 2018
PubMed

Insights

Animal models are crucial for understanding multiple sclerosis (MS) and developing treatments. This review covers common MS models like EAE and zebrafish, highlighting their roles in studying neuroinflammation and therapeutic validation.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Multiple sclerosis (MS) is a chronic, immune-mediated central nervous system demyelinating disease.
  • Animal models are essential for understanding MS pathogenesis and exploring therapeutic strategies.

Purpose of the Study:

  • To review commonly utilized animal models for multiple sclerosis research.
  • To discuss the utility of different models in recapitulating specific aspects of MS.

Main Methods:

  • Review of established animal models including Experimental Autoimmune Encephalomyelitis (EAE).
  • Discussion of toxin-induced demyelinating models.
  • Exploration of emerging Zebrafish models for MS research.

Main Results:

  • EAE models are valuable for investigating neuroinflammatory mechanisms in MS.
  • Toxin-induced models aid in understanding oligodendrocyte biology, demyelination, and remyelination.
  • Zebrafish models offer rapid development and genetic manipulability for therapeutic candidate validation.

Conclusions:

  • While no single model fully replicates MS, diverse models offer critical insights into disease mechanisms.
  • Animal models are indispensable for advancing MS research and identifying potential therapies.
  • Zebrafish present a promising platform for future MS therapeutic development.
Keywords:
Multiple sclerosisanimal modelsdemyelinationexperimental autoimmune encephalomyelitiszebrafish

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.8K
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.6K

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.1K
Tonicity in Animals00:59

Tonicity in Animals

The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
124.1K
Tonicity in Animals01:16

Tonicity in Animals

Tonicity describes the amount of solute in a solution. The measure of the tonicity of a solution, or the total amount of solutes dissolved in a specific amount of solution, is called its osmolarity. Three terms—hypotonic, isotonic, and hypertonic—are used to relate the osmolarity of a cell to the osmolarity of the extracellular fluid that contains the cells. In a hypotonic solution, such as tap water, the extracellular fluid has a lower concentration of solutes than the fluid inside...
5.2K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.2K
Multiple Regression01:25

Multiple Regression

Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K
Multiple Voltage Sources01:25

Multiple Voltage Sources

Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K