Endoworm: A new semi-autonomous enteroscopy device

Area of Science:

• Medical Devices
• Gastroenterology
• Surgical Technology

Background:

• Traditional enteroscopy for small intestine exploration faces challenges like long procedure times, patient discomfort, sedation requirements, incomplete examinations, and a steep learning curve.
• Existing methods necessitate significant training and can be taxing for patients, limiting diagnostic and therapeutic efficacy.

Purpose of the Study:

• To describe the design, development, and preliminary testing of the Endoworm enteroscopy system, a novel semi-autonomous device intended to overcome current enteroscopy limitations.
• To evaluate the performance of the Endoworm system across various experimental models, assessing its potential for improving small bowel visualization.

Main Methods:

• The Endoworm system, featuring a control unit and inflatable/deflatable cavities, was designed to retract the bowel over a standard enteroscope.
• The prototype underwent testing in a rigid tube, an in vitro model, an ex vivo porcine model, and an in vivo animal model.
• Performance was assessed by experienced medical personnel, measuring the mean distance covered per cycle.

Main Results:

• The Endoworm system demonstrated excellent performance in rigid and in vitro models, indicating successful lumen traversal.
• Ex vivo testing revealed that device performance is significantly influenced by the mechanical properties of the intestinal lumen.
• In vivo animal model experiments indicated promising results but highlighted the need for further system modifications to optimize performance.

Conclusions:

• The Endoworm enteroscopy system shows potential as an innovative approach to small intestine exploration, offering a novel mechanism for bowel retraction.
• While initial results in artificial and ex vivo models are encouraging, in vivo testing underscores the necessity for further refinement to enhance efficacy and reliability in living organisms.