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Clinical profile of measles in children with special reference to infants

T G Sindhu1, M G Geeta2, P Krishnakumar3

  • 11 Associate Professor, Department of Paediatrics, Government Medical College, Kozhikode, Kerala, India.

Tropical Doctor
|October 16, 2018
PubMed

Insights

Infants with measles often show early rash and face higher complication risks, including bronchopneumonia and sepsis. This highlights the need for early vaccination before the standard first dose.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Measles (Morbillivirus) is a highly contagious viral illness.
  • Infants are particularly vulnerable to measles complications due to immature immune systems.
  • Current vaccination schedules may not fully protect infants before disease exposure.

Purpose of the Study:

  • To analyze the clinical features of measles in infants.
  • To compare measles presentation and outcomes in infants versus older children.
  • To assess the risk of complications in infants with measles.

Main Methods:

  • Retrospective analysis of hospitalized children with suspected measles.
  • Inclusion of clinical and sociodemographic data.
  • Comparison of confirmed measles cases between infants (<1 year) and older children (>1 year).

Main Results:

  • Infants (n=24) showed early rash onset (62.5% within 3 days of fever).
  • High complication rates in infants: bronchopneumonia (71%), acute diarrhea (33%), sepsis (8%).
  • Significantly higher complication rates observed in infants compared to older children (88% vs. 65%, P=0.05).

Conclusions:

  • Infants can present atypically with measles, often before receiving the first vaccine dose.
  • Measles poses a significantly elevated risk of severe complications in infants.
  • Early recognition and potential earlier vaccination strategies for infants are warranted.

Keywords:
Asiadiseasevaccinesviral infection

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